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Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells
BACKGROUND: Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity of paclitaxel to FLCN-deficient kidney cancer cell line, UOK257. In this report, we investigate the cellular and molecular mechanism of pacli...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879005/ https://ncbi.nlm.nih.gov/pubmed/24305604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-99 |
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