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Dynamic Recognition of the mRNA Cap by Saccharomyces cerevisiae eIF4E

Recognition of the mRNA 5′ m(7)GTP cap is key to translation initiation for most eukaryotic mRNAs. The cap is bound by the eIF4F complex, consisting of a cap binding protein (eIF4E), a “scaffold” protein (eIF4G), and an RNA helicase (eIF4A). As a central early step in initiation, regulation of eIF4F...

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Autori principali: O’Leary, Seán E., Petrov, Alexey, Chen, Jin, Puglisi, Joseph D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878992/
https://ncbi.nlm.nih.gov/pubmed/24183571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.016
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