The Extra Cytoplasmic Function Sigma Factor σ(E) Is Essential for Mycobacterium tuberculosis Virulence in Mice

The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

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Detalhes bibliográficos
Main Authors: Manganelli, Riccardo, Fattorini, Lanfranco, Tan, Dejiang, Iona, Elisabetta, Orefici, Graziella, Altavilla, Giuseppe, Cusatelli, Paola, Smith, Issar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387853/
https://ncbi.nlm.nih.gov/pubmed/15102817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.3038-3041.2004
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