Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia

PURPOSE: To evaluate the clinical activity of sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive AML and monitor the emergence of secondary FLT3 tyrosine kinase domain (TKD) mutations during treatment. EXPERIMENTAL DESIGN: Six children with relapsed/refractory AML were treated with...

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Main Authors: Baker, Sharyn D., Zimmerman, Eric I., Wang, Yong-Dong, Orwick, Shelley, Zatechka, Douglas S., Buaboonnam, Jassada, Neale, Geoffrey A., Olsen, Scott R., Enemark, Eric J., Shurtleff, Sheila, Rubnitz, Jeffrey E., Mullighan, Charles G., Inaba, Hiroto
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878304/
https://ncbi.nlm.nih.gov/pubmed/23969938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1323
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