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Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production.

In addition to its well known sedative and teratogenic effects, thalidomide also possesses potent immunomodulatory and antiinflammatory activities, being most effective against leprosy and chronic graft-versus-host disease. The immunomodulatory activity of thalidomide has been ascribed to the select...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Turk, B E, Jiang, H, Liu, J O
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38783/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755512/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7552
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