Chimeric tumor necrosis factor receptors with constitutive signaling activity.
Many hormone and cytokine receptors are crosslinked by their specific ligands, and multimerization is an essential step leading to the generation of a signal. In the case of the tumor necrosis factor (TNF) receptors (TNF-Rs), antibody-induced crosslinking is sufficient to trigger a cytolytic effect....
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41697/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5376 |
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