Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
A chimeric protein capable of binding and neutralizing tumor necrosis factor (TNF) and lymphotoxin was expressed in mice transduced with a replication-incompetent adenoviral vector into which a TNF inhibitor gene had been engineered. Within 3 days following the injection of 10(9) infectious particle...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8278368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.1.215 |
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