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Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

A chimeric protein capable of binding and neutralizing tumor necrosis factor (TNF) and lymphotoxin was expressed in mice transduced with a replication-incompetent adenoviral vector into which a TNF inhibitor gene had been engineered. Within 3 days following the injection of 10(9) infectious particle...

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Библиографические подробности
Главные авторы: Kolls, J, Peppel, K, Silva, M, Beutler, B
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC42917/
https://ncbi.nlm.nih.gov/pubmed/8278368
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