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Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

A chimeric protein capable of binding and neutralizing tumor necrosis factor (TNF) and lymphotoxin was expressed in mice transduced with a replication-incompetent adenoviral vector into which a TNF inhibitor gene had been engineered. Within 3 days following the injection of 10(9) infectious particle...

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Autors principals: Kolls, J, Peppel, K, Silva, M, Beutler, B
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC42917/
https://ncbi.nlm.nih.gov/pubmed/8278368
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