A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase.

The activation of T cells by antigens or mitogens leads to the secretion of cytokines and enzymes that shape the inflammatory response. Among these molecular mediators of inflammation is a heparanase enzyme that degrades the heparan sulfate scaffold of the extracellular matrix (ECM). Activated T cel...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lider, O, Cahalon, L, Gilat, D, Hershkoviz, R, Siegel, D, Margalit, R, Shoseyov, O, Cohen, I R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7761444/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.5037
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