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Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells
Down's syndrome (DS), a major genetic cause of mental retardation, arises from triplication of genes on human chromosome 21. Here we show that DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A) and DSCR1 (DS critical region 1), two genes lying within human chromosome 21...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877759/ https://ncbi.nlm.nih.gov/pubmed/24352425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.226381.113 |
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