LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson’s disease patients: Reversal by gene correction

Parkinson’s disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitochondrial DNA (mtDNA) damage can compromise mitochon...

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Detaylı Bibliyografya
Asıl Yazarlar: Sanders, Laurie H., Laganière, Josée, Cooper, Oliver, Mak, Sally K., Vu, B. Joseph, Huang, Y. Anne, Paschon, David E., Vangipuram, Malini, Sundararajan, Ramya, Urnov, Fyodor D., Langston, J. William, Gregory, Philip D., Zhang, H. Steve, Greenamyre, J. Timothy, Isacson, Ole, Schüle, Birgitt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877733/
https://ncbi.nlm.nih.gov/pubmed/24148854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.10.013
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