Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation

The ribosomal protein S19 (RPS19) is located in the small (40S) subunit and is one of 79 ribosomal proteins. The gene encoding RPS19 is mutated in approximately 25% of patients with Diamond-Blackfan anemia, which is a rare congenital erythroblastopenia. Affected individuals present with decreased nu...

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Bibliographic Details
Main Authors: Matsson, Hans, Davey, Edward J., Draptchinskaia, Natalia, Hamaguchi, Isao, Ooka, Andreas, Levéen, Per, Forsberg, Erik, Karlsson, Stefan, Dahl, Niklas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC387766/
https://ncbi.nlm.nih.gov/pubmed/15082795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.4032-4037.2004
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