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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy
Prion diseases are linked to the accumulation of a misfolded isoform (PrP(Sc)) of prion protein (PrP). Evidence suggests that lysosomes are degradation endpoints and sites of the accumulation of PrP(Sc). We questioned whether lysosomes participate in the early quality control of newly generated misf...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877647/ https://ncbi.nlm.nih.gov/pubmed/24454378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/560421 |
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