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Misfolded PrP and a novel mechanism of proteasome inhibition
Prion diseases comprise a family of fatal neurodegenerative disorders caused by the conformational re-arrangement of a normal host-encoded protein, PrP(C), to an abnormal infectious isoform termed PrP(Sc). Currently, the precise cellular mechanism(s) underlying prion disease pathogenesis remain uncl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338962/ https://ncbi.nlm.nih.gov/pubmed/22453175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.6.1.18272 |
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