The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer

The tumor suppressor p53 is often inactivated in head and neck cancer (HNC) through TP53 mutations or overexpression of mouse double minute 2 or mouse double minute X. Restoration of p53 function by counteracting these p53 repressors is a promising strategy for cancer treatment. The present study as...

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Main Authors: Roh, J-L, Kim, E H, Park, H B, Park, J Y
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877559/
https://ncbi.nlm.nih.gov/pubmed/24336076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.488
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