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Propagation of Saccharomyces cerevisiae [PSI(+)] Prion Is Impaired by Factors That Regulate Hsp70 Substrate Binding

The Saccharomyces cerevisiae [PSI(+)] prion is believed to be a self-propagating cytoplasmic amyloid. Earlier characterization of HSP70 (SSA1) mutations suggested that [PSI(+)] propagation is impaired by alterations that enhance Ssa1p's substrate binding. This impairment is overcome by second-s...

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Bibliografiske detaljer
Main Authors: Jones, Gary, Song, Youtao, Chung, Seyung, Masison, Daniel C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC387751/
https://ncbi.nlm.nih.gov/pubmed/15082786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3928-3937.2004
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