Loss of Multi-Epitope Specificity in Memory CD4(+) T Cell Responses to B. Pertussis with Age

Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective immunity against pertussis. For better understanding of the limited immunological memory to Bordetella pertussis, we used a panel of Pertactin...

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Detalhes bibliográficos
Main Authors: Han, Wanda G. H., van Twillert, Inonge, Poelen, Martien C. M., Helm, Kina, van de Kassteele, Jan, Verheij, Theo J. M., Versteegh, Florens G. A., Boog, Claire J. P., van Els, Cécile A. C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877060/
https://ncbi.nlm.nih.gov/pubmed/24391789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083583
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