Loss of Multi-Epitope Specificity in Memory CD4(+) T Cell Responses to B. Pertussis with Age

Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective immunity against pertussis. For better understanding of the limited immunological memory to Bordetella pertussis, we used a panel of Pertactin...

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Bibliografiske detaljer
Main Authors: Han, Wanda G. H., van Twillert, Inonge, Poelen, Martien C. M., Helm, Kina, van de Kassteele, Jan, Verheij, Theo J. M., Versteegh, Florens G. A., Boog, Claire J. P., van Els, Cécile A. C. M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877060/
https://ncbi.nlm.nih.gov/pubmed/24391789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083583
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