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The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
Vinorelbine is a semisynthetic vinca alkaloid used in the treatment of advanced breast and non-small cell lung cancers. Vincristine, a related vinca alkaloid, is 9-fold more efficiently metabolized by CYP3A5 than by CYP3A4 in vitro. This study quantified the relative contribution of CYP3A4 and CYP3A...
Na minha lista:
| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876810/ https://ncbi.nlm.nih.gov/pubmed/23780963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.051094 |
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