Increased Risk of Vincristine Neurotoxicity Associated with Low CYP3A5 Expression Genotype in Children with Acute Lymphoblastic Leukemia

BACKGROUND: This study evaluates the relationship between cytochrome P450 (CYP) 3A5 genotype and vincristine-induced peripheral neuropathy in children with precursor B cell acute lymphoblastic leukemia (preB ALL). We have shown in vitro that vincristine is metabolized significantly more efficiently...

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Bibliografische gegevens
Hoofdauteurs: Egbelakin, Akinbode, Ferguson, Michael J., MacGill, Emily A., Lehmann, Amalia S., Topletz, Ariel R., Quinney, Sara K., Li, Lang, McCammack, Kevin C., Hall, Stephen D., Renbarger, Jamie L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020258/
https://ncbi.nlm.nih.gov/pubmed/21225912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22845
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