CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer

BACKGROUND: Vincristine (VCR) is a critical part of treatment in pediatric malignancies and is associated with dose-dependent peripheral neuropathy (vincristine-induced peripheral neuropathy [VIPN]). Our previous findings show VCR metabolism is regulated by the CYP3A5 gene. Individuals who are low C...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Skiles, Jodi L., Chiang, ChienWei, Li, Claire H., Martin, Steve, Smith, Ellen L., Olbara, Gilbert, Jones, David R., Vik, Terry A., Mostert, Saskia, Abbink, Floor, Kaspers, Gertjan J., Li, Lang, Njuguna, Festus, Sajdyk, Tammy J., Renbarger, Jamie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766375/
https://ncbi.nlm.nih.gov/pubmed/29115708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26854
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