Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism

Activation of metabotropic glutamate receptor subtype 5 (mGlu(5)) represents a novel strategy for therapeutic intervention into multiple central nervous system disorders, including schizophrenia. Recently, a number of positive allosteric modulators (PAMs) of mGlu(5) were discovered to exhibit in viv...

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Autors principals: Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Morrison, Ryan D., Zhou, Ya, Gogliotti, Rocco D., Vinson, Paige N., Xiang, Zixiu, Jones, Carrie K., Niswender, Colleen M., Lindsley, Craig W., Stauffer, Shaun R., Conn, P. Jeffrey, Daniels, J. Scott
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876804/
https://ncbi.nlm.nih.gov/pubmed/23821185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052084
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