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Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric disorders, including those characterized by the presence of repetitive behaviors. We developed an optogenetic approach to block repetitive, compulsive behavior in a mouse model in which deletion of the synaptic sc...

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Hlavní autoři: Burguière, Eric, Monteiro, Patrícia, Feng, Guoping, Graybiel, Ann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876800/
https://ncbi.nlm.nih.gov/pubmed/23744950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232380
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