Elicitation of Neutralizing Antibodies with DNA Vaccines Expressing Soluble Stabilized Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers Conjugated to C3d

DNA vaccines expressing the envelope (Env) of human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting immune responses. Oligomeric or trimeric (gp140) forms of Env that more closely mimic the native proteins on the virion are often more eff...

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Vydáno v:J Virol
Hlavní autoři: Bower, Joseph F., Yang, Xinzhen, Sodroski, Joseph, Ross, Ted M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2004
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15078953/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.9.4710-4719.2004
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