Elicitation of Neutralizing Antibodies with DNA Vaccines Expressing Soluble Stabilized Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers Conjugated to C3d

DNA vaccines expressing the envelope (Env) of human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting immune responses. Oligomeric or trimeric (gp140) forms of Env that more closely mimic the native proteins on the virion are often more eff...

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Detalhes bibliográficos
Main Authors: Bower, Joseph F., Yang, Xinzhen, Sodroski, Joseph, Ross, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387675/
https://ncbi.nlm.nih.gov/pubmed/15078953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4710-4719.2004
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