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1,25-Dihydroxyvitamin D(3) selectively and reversibly impairs T helper-cell CNS localization

Pharmacologic targeting of T helper (T(H)) cell trafficking poses an attractive opportunity for amelioration of autoimmune diseases such as multiple sclerosis (MS). MS risk is associated with vitamin D deficiency, and its bioactive form, 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has been shown to...

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Detalhes bibliográficos
Main Authors: Grishkan, Inna V., Fairchild, Amanda N., Calabresi, Peter A., Gocke, Anne R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876241/
https://ncbi.nlm.nih.gov/pubmed/24324134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306072110
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