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Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells
Double-negative T (DNT) cells are αβTCR(+)CD3(+)CD4(−)CD8(−)NK1.1(−) cells that constitute a small but significant proportion of the αβTCR(+) T cells. Their developmental pathway and pathological significance remain unclear. In the present study, we utilized chronic in vitro stimulation of CD4(+) T...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788052/ https://ncbi.nlm.nih.gov/pubmed/23933188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2013.06.011 |
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