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Importance of H-Abstraction in the Final Step of Nitrosoalkane Formation in the Mechanism-Based Inactivation of Cytochrome P450 by Amine-Containing Drugs

The metabolism of amine-containing drugs by cytochrome P450 enzymes (P450s) is prone to form a nitrosoalkane metabolic intermediate (MI), which subsequently coordinates to the heme iron of a P450, to produce a metabolic-intermediate complex (MIC). This type of P450 inhibition, referred to as mechani...

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Библиографические подробности
Главные авторы: Hirao, Hajime, Thellamurege, Nandun M., Chuanprasit, Pratanphorn, Xu, Kai
Формат: Artigo
Язык:Inglês
Опубликовано: Molecular Diversity Preservation International (MDPI) 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876136/
https://ncbi.nlm.nih.gov/pubmed/24351842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms141224692
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