Mechanism-Based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-Containing Compounds

Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 667...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Bolles, Amanda K., Fujiwara, Rina, Briggs, Erran D., Nomeir, Amin A., Furge, Laura Lowe
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244870/
https://ncbi.nlm.nih.gov/pubmed/25273356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.060459
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