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Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug

An investigational anticancer agent that contains a thiophene moiety, 3-[(quinolin-4-ylmethyl)-amino]-N-[4-trifluoromethox)phenyl] thiophene-2-carboxamide (OSI-930), was tested to investigate its ability to modulate the activities of several cytochrome P450 enzymes. Results showed that OSI-930 inact...

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Main Authors: Lin, Hsia-lien, Zhang, Haoming, Medower, Christine, Hollenberg, Paul F., Johnson, William W.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033695/
https://ncbi.nlm.nih.gov/pubmed/21068193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.034074
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