Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress

BACKGROUND: Congenital human cytomegalovirus (HCMV) infection, a leading cause of birth defects, is most often manifested as neurological disorders. The pathogenesis of HCMV-induced neurological disorders is, however, largely unresolved, primarily because of limited availability of model systems to...

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Detalhes bibliográficos
Main Authors: Nakamura, Hiroyuki, Liao, Huanan, Minami, Kahori, Toyoda, Masashi, Akutsu, Hidenori, Miyagawa, Yoshitaka, Okita, Hajime, Kiyokawa, Nobutaka, Umezawa, Akihiro, Imadome, Ken-Ichi, Inoue, Naoki, Fujiwara, Shigeyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875896/
https://ncbi.nlm.nih.gov/pubmed/24144363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2042-4280-4-2
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