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MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells
The melanoma differentiation-associated gene-7 (mda-7) is a known mediator of apoptosis in cancer cells but not in normal cells. We hypothesized that MDA-7 interferes with the prosurvival signaling pathways that are commonly altered in cancer cells to induce growth arrest and apoptosis. We also iden...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3875403/ https://ncbi.nlm.nih.gov/pubmed/21546925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.20 |
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