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MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells

The melanoma differentiation-associated gene-7 (mda-7) is a known mediator of apoptosis in cancer cells but not in normal cells. We hypothesized that MDA-7 interferes with the prosurvival signaling pathways that are commonly altered in cancer cells to induce growth arrest and apoptosis. We also iden...

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Detalhes bibliográficos
Main Authors: Valero, V, Wingate, H, Chada, S, Liu, Y, Palalon, F, Mills, G, Keyomarsi, K, Hunt, KK
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875403/
https://ncbi.nlm.nih.gov/pubmed/21546925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.20
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