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Hi-C: A comprehensive technique to capture the conformation of genomes
We describe a method, Hi-C, to comprehensively detect chromatin interactions in the mammalian nucleus. This method is based on Chromosome Conformation Capture, in that chromatin is crosslinked with formaldehyde, then digested, and re-ligated in such a way that only DNA fragments that are covalently...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3874846/ https://ncbi.nlm.nih.gov/pubmed/22652625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2012.05.001 |
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