G(βγ) Independent Recruitment of G-Protein Coupled Receptor Kinase 2 Drives TNFα-Induced Cardiac Beta-Adrenergic Receptor Dysfunction

BACK GROUND: Pro-inflammatory cytokine tumor necrosis factor α (TNFα) induces β-adrenergic receptor (βAR) desensitization, but mechanisms proximal to the receptor in contributing to cardiac dysfunction are not known. METHODS AND RESULTS: Two different pro-inflammatory transgenic mouse models with ca...

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Detalhes bibliográficos
Main Authors: Vasudevan, Neelakantan T., Mohan, Maradumane L., Gupta, Manveen K., Martelli, Elizabeth E., Hussain, Afshan K., Qin, Yilu, Chandrasekharan, Unni M., Young, David, Feldman, Arthur M., Sen, Subha, Dorn, Gerald W., DiCorleto, Paul E., Naga Prasad, Sathyamangla V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874808/
https://ncbi.nlm.nih.gov/pubmed/23785004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.003183
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