Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed was created. The transfection of RCSN-3 cells with a bicistronic plasmid codin...

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Detaylı Bibliyografya
Asıl Yazarlar: Muñoz, Patricia, Paris, Irmgard, Sanders, Laurie H., Greenamyre, J. Timothy, Segura-Aguilar, Juan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874718/
https://ncbi.nlm.nih.gov/pubmed/22483869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.03.010
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