DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of aminochrome determined by Western blot, transmission electron microscopy, circular dich...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Muñoz, Patricia, Cardenas, Sergio, Huenchuguala, Sandro, Briceño, Andrea, Couve, Eduardo, Paris, Irmgard, Segura-Aguilar, Juan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Protective Role of DT-Diaphorase in Alpha-Synuclein Toxicity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833033/
https://ncbi.nlm.nih.gov/pubmed/25634539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv016
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