Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts

One of the key oncogenic pathways involved in melanoma aggressiveness, development and progression is the RAS/BRAF/MEK pathway, whose alterations are found in most patients. These molecular anomalies are promising targets for more effective anti-cancer therapies. Some Mek inhibitors showed promising...

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Bibliographische Detailangaben
Hauptverfasser: Sette, Giovanni, Fecchi, Katia, Salvati, Valentina, Lotti, Fiorenza, Pilozzi, Emanuela, Duranti, Enrico, Biffoni, Mauro, Pagliuca, Alfredo, Martinetti, Daniela, Memeo, Lorenzo, Milella, Michele, De Maria, Ruggero, Eramo, Adriana
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874650/
https://ncbi.nlm.nih.gov/pubmed/24238212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-91
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