The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action remain unclear. Here, we establish that γH2AX foci, indicative of DNA double strand breaks, accumulate in a time-dependent manner in the drug sensitive MCF-7 cells but not in the resistant counterparts in response...

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Autors principals: Monteiro, Lara J., Khongkow, Pasarat, Kongsema, Mesayamas, Morris, Joanna R., Man, Cornelia, Weekes, Daniel, Koo, Chuay-Yeng, Gomes, Ana R., Pinto, Paola H., Varghese, Vidhya, Kenny, Laura M., Coombes, R. Charles, Freire, Raimundo, Medema, René H., Lam, Eric W.-F.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874579/
https://ncbi.nlm.nih.gov/pubmed/23108394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.491
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