Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson’s disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neuro...

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Main Authors: Henderson, Brandon J., Srinivasan, Rahul, Nichols, Weston A., Dilworth, Crystal N., Gutierrez, Diana F., Mackey, Elisha D.W., McKinney, Sheri, Drenan, Ryan M., Richards, Christopher I., Lester, Henry A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874574/
https://ncbi.nlm.nih.gov/pubmed/24378908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311102
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