Trafficking of α4* Nicotinic Receptors Revealed by Superecliptic Phluorin: EFFECTS OF A β4 AMYOTROPHIC LATERAL SCLEROSIS-ASSOCIATED MUTATION AND CHRONIC EXPOSURE TO NICOTINE

We employed a pH-sensitive GFP analog, superecliptic phluorin, to observe aspects of nicotinic acetylcholine receptor (nAChR) trafficking to the plasma membrane (PM) in cultured mouse cortical neurons. The experiments exploit differences in the pH among endoplasmic reticulum (ER), trafficking vesicl...

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Dettagli Bibliografici
Autori principali: Richards, Christopher I., Srinivasan, Rahul, Xiao, Cheng, Mackey, Elisha D. W., Miwa, Julie M., Lester, Henry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173132/
https://ncbi.nlm.nih.gov/pubmed/21768117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256024
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