Cytoplasmic localization of Hug1p, a negative regulator of the MEC1 pathway, coincides with the compartmentalization of Rnr2p-Rnr4p

The evolutionarily conserved MEC1 checkpoint pathway mediates cell cycle arrest and induction of genes including the RNR (Ribonucleotide reductase) genes and HUG1 (Hydroxyurea, ultraviolet, and gamma radiation) in response to DNA damage and replication arrest. Rnr complex activity is in part control...

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Detalhes bibliográficos
Main Authors: Ainsworth, William B., Hughes, Bridget Todd, Au, Wei Chun, Sakelaris, Sally, Kerscher, Oliver, Benton, Michael G., Basrai, Munira A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874403/
https://ncbi.nlm.nih.gov/pubmed/24012676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.08.089
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