Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz Syndrome (SLOS)

BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is an inborn error of cholesterol biosynthesis characterized by diminished cholesterol and increased 7-dehydrocholesterol (7-DHC) levels. 7-DHC is highly reactive, giving rise to biologically active oxysterols. METHODS: 7-DHC-derived oxysterols were meas...

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Библиографические подробности
Главные авторы: Korade, Zeljka, Xu, Libin, Harrison, Fiona E., Ahsen, Refayat, Hart, Sarah E, Folkes, Oakleigh M, Mirnics, Karoly, Porter, Ned A
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874268/
https://ncbi.nlm.nih.gov/pubmed/23896203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.06.013
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