Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in Fragile X mice

BACKGROUND: Identifying feasible therapeutic interventions is crucial for ameliorating the intellectual disability and other afflictions of Fragile X Syndrome (FXS), the most common inherited cause of intellectual disability and autism. Hippocampal glycogen synthase kinase-3 (GSK3) is hyperactive in...

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Hlavní autoři: Franklin, Aimee V., King, Margaret K., Palomo, Valle, Martinez, Ana, McMahon, Lori L., Jope, Richard S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874248/
https://ncbi.nlm.nih.gov/pubmed/24041505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.08.003
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