Miravirsen (SPC3649) can inhibit the biogenesis of miR-122

MicroRNAs (miRNAs) are short noncoding RNAs, which bind to messenger RNAs and regulate protein expression. The biosynthesis of miRNAs includes two precursors, a primary miRNA transcript (pri-miRNA) and a shorter pre-miRNA, both of which carry a common stem-loop bearing the mature miRNA. MiR-122 is a...

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Bibliografiske detaljer
Main Authors: Gebert, Luca F. R., Rebhan, Mario A. E., Crivelli, Silvia E. M., Denzler, Rémy, Stoffel, Markus, Hall, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874169/
https://ncbi.nlm.nih.gov/pubmed/24068553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt852
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