Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level

Hepatic miR-122 can serve as a pro-apoptotic factor to suppress tumorigenesis. The underlying mechanism, however, remains incompletely understood. Here we present the first evidence that miR-122 promotes hepatocellular carcinoma cell apoptosis through directly silencing the biogenesis of cell surviv...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wang, Dong, Sun, Xinlei, Wei, Yao, Liang, Hongwei, Yuan, Min, Jin, Fangfang, Chen, Xi, Liu, Yuan, Zhang, Chen-Yu, Li, Limin, Zen, Ke
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829740/
https://ncbi.nlm.nih.gov/pubmed/29253196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1254
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