Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome

Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus contributing to ageing. Approximately 1% of the population inherits a chromosomally integrated copy of human herpesvirus 6 (CI-HHV-6), but the...

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Detalhes bibliográficos
Main Authors: Huang, Yan, Hidalgo-Bravo, Alberto, Zhang, Enjie, Cotton, Victoria E., Mendez-Bermudez, Aaron, Wig, Gunjan, Medina-Calzada, Zahara, Neumann, Rita, Jeffreys, Alec J., Winney, Bruce, Wilson, James F., Clark, Duncan A., Dyer, Martin J., Royle, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874159/
https://ncbi.nlm.nih.gov/pubmed/24057213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt840
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