Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment

The secondary structures of amyloidogenic proteins are largely influenced by various intra and extra cellular microenvironments and metal ions that govern cytotoxicity. The secondary structure of a prion fragment, PrP(111-126), was determined using circular dichroism (CD) spectroscopy in various mic...

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Main Authors: Inayathullah, Mohammed, Satheeshkumar, K. S., Malkovskiy, Andrey V., Carre, Antoine L., Sivanesan, Senthilkumar, Hardesty, Jasper O., Rajadas, Jayakumar
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874036/
https://ncbi.nlm.nih.gov/pubmed/24386462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085160
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