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Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment
The secondary structures of amyloidogenic proteins are largely influenced by various intra and extra cellular microenvironments and metal ions that govern cytotoxicity. The secondary structure of a prion fragment, PrP(111-126), was determined using circular dichroism (CD) spectroscopy in various mic...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3874036/ https://ncbi.nlm.nih.gov/pubmed/24386462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085160 |
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