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DEMETHYLATING AGENTS IN MYELOID MALIGNANCIES
PURPOSE OF REVIEW: Two demethylating agents are approved in myelodysplastic syndromes (MDS): 5-azacitidine and 5-aza-2′-deoxycitidine (decitabine). These drugs are structurally related and induce DNA hypomethylation. Aberrant DNA methylation is associated with gene silencing. It is proposed that hyp...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873866/ https://ncbi.nlm.nih.gov/pubmed/18841054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCO.0b013e328313699c |
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