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DEMETHYLATING AGENTS IN MYELOID MALIGNANCIES

PURPOSE OF REVIEW: Two demethylating agents are approved in myelodysplastic syndromes (MDS): 5-azacitidine and 5-aza-2′-deoxycitidine (decitabine). These drugs are structurally related and induce DNA hypomethylation. Aberrant DNA methylation is associated with gene silencing. It is proposed that hyp...

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Bibliografische gegevens
Hoofdauteur: Garcia-Manero, Guillermo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873866/
https://ncbi.nlm.nih.gov/pubmed/18841054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCO.0b013e328313699c
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